生酮飲食的歷史及其簡易科學原理

生酮飲食的歷史

生酮飲食要從1910年代的幾位醫生讓病人「挨餓」後,有效改善癲癇症狀開始說起,這些醫生發現,在挨餓三、四天後,癲癇病人的大腦狀況會得到改善。而在1920年代Dr. Woodyatt & Wilder則進一步發現,攝取極低的碳水化合物、搭配高比例的脂肪,不僅可以得到類似的效果,因為病人可以進食,還可以大幅提升療程的持續時間,比單純的「挨餓療法」來得更好用,這便是「生酮飲食」的由來。

1922年介紹生酮飲食的報導。圖片來源:Wiki



生酮飲食此後受到廣泛歡迎,在1940-1980年代達到巔峰,當時更有一個調查結果指出,在1000位使用生酮飲食的癲癇兒童中,52%完全康復、27%得到相當的改善。此後,生酮飲食正式被列為治療癲癇的療法之一,幾乎所有與兒童癲癇有關的教科書,都會花上一整個章節來討論生酮飲食。


可惜自1970年代開始,當治療幼兒癲癇的藥物陸續問世,實行不易、需要營養師精算的生酮飲食療法就慢慢沒落了。然而,NBC的一部紀錄片,又再度燃起了科學界對於生酮飲食的研究,這部影集是敘述一位罹患癲癇的兩歲男孩的人生轉折、一個普通家庭如何因為癲癇以及拜金主義的醫療制度而陷入絕境、最終父母拒絕手術、採用生酮飲食後卻得到意想不到的治療效果。該片大受歡迎,後來甚至還由這位男孩的父親執導,在1997年拍攝了梅莉史崔普飾演的「不要傷害我小孩 (First Do No Harm)


「First Do No Harm」宣傳海報。

劇中患有癲癇小孩吃的就是生酮飲食標準配備:炒蛋、培根。

至近代,因為廣泛的研究,生酮飲食已被列為治療神經退化性疾病(例如阿茲海默症、帕金森氏症、多發性硬化等)、創傷性腦部受損(例如腦震盪)甚至是癌症的療法之一。


而生酮飲食約在1990年代開始受到健美運動員的關注,這群人在乎的當然不是生酮飲食對於大腦的影響,而是生酮飲食的副作用:降低體脂肪


想想看, 餐餐大吃牛排、起司、奶油、橄欖油,卻能同時擁有線條分明的腹肌?也太不科學了吧!


有許多健美運動員都為生酮飲食「降低體脂肪」的副作用深深著迷,自然也陸續有商人打著「教學」的口號,販售生酮飲食的指導。

時至今日,這套神奇的飲食方法又得到了更大量的關注,除了想練更大、練壯的健美先生之外,想提升表現的運動員、想減脂的人們,都把眼光放到了這套飲食系統上。生酮飲食可以讓我跑得更快嗎?可以改善家中長輩的病嗎?可以讓我擁有一個完美的Beach-body嗎?


答案是:真的不一定,看情況。


看了半天,什麼時候才要講重點啦?



什麼啊?你講了這麼多,結果到頭來還是「不一定」?


對啦!怎樣?打我啊!因為生酮飲食大幅度地改變了身體的運作模式,並不是三言兩語就可以解釋清楚的,而且在不同的變因(如運動、蛋白質攝取量等)下會有不同的效果,如果我隨便就下結論,那就太不負責任了,就讓我向各位娓娓道來…


首先,我們需要了解的的就是生酮飲食的科學原理。


生酮飲食的簡易科學原理


大腦是人體中數一數二重要的器官,消耗的能量也特別大,但因為脂肪分子過大、無法穿越血管障蔽至大腦利用,大腦別無選擇,只能成為「葡萄糖」的狂熱粉絲。正常狀況下體內60-70%的葡萄糖都會優先供應給大腦作為主要燃料。


但人體儲存「葡萄糖」的能力相當差,多餘的醣類都會被轉化成「肝醣」儲存,但肝醣當然可以再轉回變成葡萄糖,所以正常狀況下,當體內葡萄糖濃度過低、大腦沒燃料可以燒的時候,只要跟肝臟說一聲,肝醣轉換一下、新的葡萄糖就會運過來了。


肝臟對大腦的燃料供應至關重要。這個循環我從來沒有背起來過,大學考生化時都直接放棄。來源:Melo TM et al..



(身體儲存的肝醣與脂肪相比,是「相對」重的,就是儲存能量的CP值比較低,所以人體儲存碳水化合物的能力比脂肪低很多,大概是1000大卡對上150,000大卡的差距)


但當我們飢餓、體內的葡萄糖跟肝醣都消耗殆盡的時候(約二至三天),你就會因為大腦沒有能量變成腦殘了


Google “idiot” 後看到滿滿都是Trump的照片…在此聲明我沒有政治立場XD)


恩,當然……. 不是! 如果好幾天沒吃東西就變成腦殘,那人類怎麼可能在古代激烈的生存競爭中存活下來?


快摸摸肚子上那一圈又一圈的肉吧!難道他們是裝飾用的嗎?脂肪的角色就是在身體沒有食物時的能量來源。但是我們剛剛有講到,脂肪分子太大進不了大腦、而大腦愛吃的葡萄糖偏偏又不夠用,那怎麼辦?


身體有個很聰明的機制,基本上一個人餓超過72小時不吃東西,體內的葡萄糖、肝醣耗竭、又沒有辦法透過食物補充的時候,肝臟可以透過生酮作用(Ketogenesis) 將脂肪轉換成「酮體」 (Ketone body) ,並將你的身體轉變為「酮症」 (Ketosis) 狀態。大腦可以改用這些酮體作為主要燃料、並降低葡萄糖的使用量,同時身體其他部位也會改以大量燃燒脂肪作為能量來源。(註)

在正常狀況下大腦都是使用葡萄糖作為能量來源。但在飢餓時,大腦可以改使用酮體、並減少葡萄糖的消耗。來源:Ketosis proportionately spares glucose utilization in the brain (Zhang et al., 2013)
我們可以把「酮症狀態」看成是人體能量系統的緊急方案,可以讓人體在很長一段的時間不進食後,依然能夠維持大腦正常運作。


至於要挨餓多久才可以進入酮症狀態,速度因人而異,不過相比於其他哺乳類動物,人類因為需要把接近20%攝取的總能量供應給大腦,因此有著最快速的酮症反應,以應付龐大的大腦能量需求。頭佔身體比例最高的小嬰兒,甚至可以在幾個小時沒有進食後就達到酮症狀態;但對健康的成人來說,若要進入酮症,可能要挨餓好幾天、甚至一個禮拜。


挨餓好幾天後進入「酮症」狀態對多數人來說不僅相當痛苦,也很不划算。目前已有大量研究指出,挨餓所減輕的體重會伴隨著可觀的肌肉流失(約是減輕的體重的25%),因此,在多數情況下,「挨餓」來進入「酮症」並不會被採用。


延伸閱讀:酮症與酮酸中毒的差別?

請注意,在閱讀各類文獻時,別把ketosisketoacidosis搞混。酮症 (Ketosis) 泛指血液中的酮體高於正常數值時,而酮酸中毒(ketoacidosis)發生在當血液中的酮體高到無法控制並損害正常機能的時候。正常人的身體自我調節能力非常強,當血液偏酸的時候,身體可以藉著產生更多的生物鹼來吸收氫離子以緩衝(高中的緩衝溶液概念)、或者讓腎臟來幫忙。但在某些情況下,當身體緩衝的能力不足以應付過高濃度的氫離子,血液的pH值低於7.35的時候,麻煩就大了,這個才叫做酮酸中毒。酮酸中毒較常發生在代謝系統出問題的人身上,對於身體健康的一般人而言,就算施行生酮飲食,也很難真的「一下就把身體給吃壞」。

對這個議題有興趣的朋友,可以參考史考特的一分鐘教室這篇文章



生酮飲食:不用挨餓、卻一樣可以達到「酮症」的效果

由於「酮症」需要長時間的飢餓後才會產生,現實生活中施行不易,所以科學家觀察到另外一個方法,也就是使用「生酮飲食」。


這種方法不用真的餓肚子,只要大幅降低碳水化合物的攝取量,並將不足的熱量缺口用額外的脂肪與蛋白質補足,身體就會產生類似「饑荒」的反應、並進入「酮症」狀態,開始大量燃燒脂肪供應身體能量需求。


哇!聽起來合情合理耶!而且看起來生酮飲食在科學的解釋上面也沒有什麼瑕疵,所以我只要馬上開始吃,就會變瘦嗎?!


可惜的是,世界沒有這麼美好。除了身體運作的機制超乎想像的複雜之外,生酮飲食對一般人而言實施起來也很不容易。這也是為什麼大部分人的生酮飲食計劃,都會以失敗收場

下一篇文章,我們將會探討


生酮飲食要怎麼吃?又要如何才能達到理想效果?


註:(延伸閱讀)
「酮體」是由一群特定結構的化學物質的通稱,最早約在1950年代德國化學家Gmelin所命名。人體可以利用的酮體有兩種,分別是acetoacetate以及D-β-hydroxybutyrate,而身體產生酮體的方式相當複雜,簡而言之就是在特定情境之下(例如飢餓狀態、或者是刻意降低碳水化合物的攝取時),體內會有下列反應:

脂肪組織釋放脂肪酸->脂肪酸進入細胞中脂肪酸與co-enzyme A形成acetyl-Co-A chain並進入肝臟細胞的粒線體 β-Oxidation 後的產物形成acetyl-Co-A經過一系列酵素轉換後生成前述的兩種酮體、以及Acetone  酮體進入血液中 需要能量的細胞便可以使用這些酮體作為能量來源。


β-Oxidation 後的產物:Acetone以及兩種酮體 









有些人會把酮體比喻為除了碳水化合物、脂肪與蛋白質之外的「第四種」能量系統,我認為這比喻算是滿貼切的。

(不過,酮體就如酒精一樣,人體雖然可以分解利用並產生能量,但這並不代表我們就應該使用它們為主要能量來源

肝臟還有另一個自己合成葡萄糖的機制稱為醣質新生(gluconeogenesis),可以把體內的氨基酸以及其他物質轉化成葡萄糖供大腦使用。

這兩個機制就是人類就算好幾天沒吃東西,也不會因為醣類用光就變腦殘的原因。

(如果對以上兩個反應途徑有興趣的朋友,可以至史考特醫生的一分鐘健身教室這篇文章、還有這篇文章看看)
Reference:

Wheless, J. W. (2008), History of the ketogenic diet. Epilepsia 3–5. doi:10.1111/j.1528-1167.2008.01821.x

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(六)三個禮拜在美國找到工作之經驗分享(上)


Please inform me about you?

Which direct you to go for a career as a coach?
因為我有上GoogleGlassdoor查過,整體回答還滿順利的,HR隨後表示會有下一輪與店經理的電話面試。

其實不管哪間公司,問的問題都差不多是這些,事前先把想講的東西擬好稿後再練習講幾次,大概就背起來了。但不能在電話面試時照唸,除了語調不自然之外,現場面試時也容易破功,反而不好。

要在使用英文的當下講出有條理、有內容的回答並不容易,適當的擬稿可以提供很大的幫助。

我最後在電話中有詢問這個實習有沒有給薪、還有大致的工作內容,結果不僅不支薪、也不能真的訓練客人,雖然職務敘述上寫得很好聽(可以獲得實務經驗、了解公司運作,但大概就是在旁邊觀察跟打雜),所以我就說可不可以改成應徵正職,HR也說他覺得我的經歷可能有機會,若成功錄取,會請面試的經理依我的表現做出決定。

第二輪
Private Training Manager (Shane) 的電話面試,除了HR問過的問題全部再問一輪之外,還有一些比較詳細的背景調查、還有一些與專業有關的問題,例如:
What’s your educational background and what certificate you might have?
Have you got past experience on instruction somebody? What did you realize?
What is your coaching style? How can you keep your own client?
因為一樣有上網準備,加上事前的大量練習,回答的也頗順利,隨後Shane就約我去他所在的Equinox據點進行現場面試。

第三輪
Shane一對一的面試,他以前是橄欖球員,除了身材厚實之外、講話也很直接。他見面就直接劈頭問我 Are you currently authorized to operate at the U.S? Let’s talk about it.  因為我沒有身份、而且Equinox不會sponsor教練辦H1B工作簽(除非將來能升到其他職位),所以他必須先確認我的身份問題還有工作時間才能繼續。在簡單敘述了CPT+OPT可以讓我合法工作至少一年半後,他才丟出其他面試的問題。這次的問題又更詳細了一些,他除了拿著我的履歷一條一條問之外,還有:
If there’s a penis walk to you and ask how to lose weight, what would you do to make the manhood finally buy your coaching sessions?
Give me two of your strength and weakness?
What is your 5-year plan?
一樣,因為有事先準備題庫跟大量練習,回答得很順利,得到了最後一關團體面試的邀請。

第四輪
團體面試,主要是測個性、團隊合作還有專業知識。那天加上我共有4個人,two 個黑人大個、1個白人女生、還有我,41。面試者除了Shane之外還有General Manager。在所有人都到齊後,我們直接被帶到Club團體課的瑜伽教室。團體面試總共有三關,都是由Shane主持,GM在旁邊只負責觀察、紀錄還有評分。

Equinox 92st 簡單卻寬敞的木板教室,當天大家就席地而坐進行團體面試


第一關Ice breaker
有點類似自我介紹的接龍,但每個人的自我介紹要跟前面的人做一點連結並自由發展,例如ShaneThat is Shane, I have two kids and I like playing with my dog. 那下一個人(假設是我)就要說I am Martin, I don’t have kids like Shane, but I’ll have 10 in the future so that they can play basketball and that I are the referee. 然後就是這樣一直輪下去講。這關還滿輕鬆的,目的除了讓大家彼此認識之外,也想要看你的個性如何。他們想要開朗、健談、幽默的人。我知道他們想看到什麼,雖然英文不是特別好,但我就亂掰一些北爛的東西,別人講的內容我也會時不時吐槽一下或做回應。

第二關 Ability Evaluation
一開始Shane就說他需要一個Volunteer,誰要自願,由於我那天是處在一個「一定要積極、丟臉也沒差」的超級賽亞人狀態,完全豁出去了,雖然不知道要幹嘛,但還是勇敢地舉起了我的手大聲說I can get it done!  隨後Shane就請我到中間做10個深蹲,並請所有人專心觀察並指出我動作上的瑕疵。我做完之後,另外三個面試者都陷入沈思(其實這個時候我還滿慶幸的,因為在學校有做過比較深蹲、前蹲的報告,所以深蹲常見錯誤我都有幫自己檢視過並矯正),最後大家當然還是都舉手硬著頭皮講,有一個說他覺得我腳尖太開、另一個說我蹲下去的時候身體是斜的沒有直立、還有一個說我沒有蹲到最底、訓練效果不好。

Shane聽完大家的回答就說,第一個,Martin在蹲的時候你們都沒有站起來從各種角度觀察、坐在原地看會有很多盲點,希望你們以後要記住這點。後面再跟大家解釋說,腳尖朝外角度、身體前傾角度、蹲下去多深,都沒有真正的限制,只要維持脊椎中立、骨盆膝蓋穩定、腳跟著地,其他變數都因為每個人的生理條件而異。在他的觀點看來我的Squat幾乎沒有缺點,硬要講的話就是右腳踝有些不穩定會有輕微晃動(我右腳開了三次刀的確很不穩定,有經驗的教練果然可以看出很多東西)

接著就是另外三個人輪流上去做Squat Push-up、台下的人觀察並指出瑕疵,一樣的流程。不過我在台下的時候真的就是超級賽亞人,而我的競爭者多數自己上台示範時動作都不完美之外,他們也看不太出動作中比較細微的瑕疵,所以到後面到都只剩我在發言。 除了簡單的膝蓋內旋、蹲下去重心偏離這種初階教練該要看得出來的錯誤之外,像是Butt wink, Excessive fur pronation, Scapula wings這種比較進階的錯誤,我都批哩啪拉說出來,還有人請我解釋這些名詞最後每個人都示範過一次動作後,第二關結束。

第三關 Programming Test
這關要2人一組合作設計運動菜單。Shane給每組一張紙,上面是一個客戶的資料,除了年齡、身高、體重、體脂肪等基本數據之外,也有如VO2max、血壓、血糖、家族病史、目前服用藥物等等。他假設這位客戶一個禮拜會來上兩次教練課,那我們要如何為這位客戶設計運動菜單?十五分鐘內完成,並要派出一人用two 分鐘向大家報告。

我的題目是個65歲患有椎間盤突出的老太太,目標是在三個月內瘦10磅、還有強化生活機能(functional living),除了體脂肪偏高還有椎間盤突出之外,她所有數據都很正常,甚至還有一個超級高的VO2Max因為我有ACSM的訓練,所以這題對我來說滿輕鬆的、題目裡的進階數據我也是在場四位面試者中唯一看得懂且能運用的,所以看到這題目我完全鬆了一口氣。

我的搭檔是一位黑人老兄,基本上他就是個練得很壯、但知識較不足的大個(或者他比較沒接觸過特殊族群),所以討論的過程中都是我在主導,我講什麼他都說Yeah you are right. 我們最後的討論結果是,因為這位老太太的VO2Max超強,基本上不用太擔心她的有氧,規律運動搭配飲食控制就可以慢慢瘦下來。而若想強化生活機能,那下半身的肌力及肩膀活動度是最重要的,所以會先讓這位老太太做無負重的Overhead squat (必要時可以搭配彈力球與靠牆以增加穩定性),看看她的肌力及肩膀狀況如何,並為之設計之後的菜單;而椎間盤突出的話可能在重訓方面要先保守一點,初期將會以機器、肌耐力訓練為主,並視情況加入Free-weight,若要硬舉跟深蹲可能都不需要到很重,並轉介物理治療師處理。類似的東西我講了很多,2分鐘根本不夠,但是Shane在時間到的時候就說Oops up times but please keep moving ,所以我又繼續講了整整講了五分鐘吧在兩組都發表完之後,整個團體面試結束。

結果
我隔天就接到Shane的電話了,想當然他是來告知結果的,看到來電心就怦怦狂跳,雖然大概知道自己的表現是所有面試者中最好的,但因為身份、語言的問題,我還是很怕被打槍。Shane在電話那頭說:

「我們昨天完整看見了你的專業、而且英文口語良好,溝通絕對沒問題。但你有時候講話的方式因為文化差異可能會讓客人不適應、在這產業經驗也還不夠(聽到這句我都快哭了,覺得大概要GG了)但是

這些都是小缺點,無法掩蓋你的優秀。只要給我們一些時間,我們會幫你改善。你完全擁有正職教練該有的能力,事實上你可能是我這幾年來遇過最專業的應徵者,So let us bypass the intern and we’ll provide you a fulltime Offer with all the advantages 」

當下真的…感動到說不出一句話,我大概整整傻了三秒吧,直到Shane說”So…What would you really think? You may take the offer?  我當然是說 Yes sure, I am so thankful to be one of Equinox.

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How Mimi’s Using The SCD Diet To Reverse Type 2 Diabetes

Among the most powerful tools there is when it comes to getting our health back is not the ideal diet program or all of the right supplements…

It’s our attitude.

I am aware of , we get it – a favorable attitude might be the last thing in your mind while you’re sick….

But it may be the difference between having your health back and staying sick.

Steve, myself and Mimi – we had major setbacks on the path to getting healthy.

Plus it was a positive attitude that gave us the power to keep moving forward – to maintain tweaking, adapting and adjusting.

When those ideas of negativity crept in, it was Mimi’s can-do attitude that gave her the strength to make that one life-changing adjustment.

The modification that helped her overcome IBS (Irritable Bowel Syndrome) and Type 2 Diabetes.

If you’ve lost confidence, you can not find the light at the end of the tunnel, or are just plain tired of being ill, this story is for you.

[Input Mimi]

IBS Along With Diabetes Controlled My Life

Four decades back, I was dealing with major indicators of Type 2 diabetes along with IBS (Irritable Bowel Syndrome). This included everything in horrible stomach pain, higher blood pressure, fatigue, itchy skin, blood sugar swings and depression to more digestive problems and spells of confusion.

The digestive issues got so bad I couldn’t get through the afternoon without running to a toilet in severe pain. (I actually had regular tummy problems as far back as 10 decades ago, but didn’t listen as I should have.)

I Ended Up At The Emergency Room

1 afternoon, the principal at our school sent me home because of her observation which I appeared exhausted and not able to see the young kindergarten kids in my care. I left really upset and drove directly for my doctors office, in which they invited me to go right to the emergency area.

I was diagnosed with Type 2 diabetes, as my blood glucose was nearly 600 mg/dl. While in the hospital, I experienced three grand mal seizures and almost died.

It is just from the grace of God that I lived this period of my life.

I Spent The following Year In And Out Of Doctor’s Heads

Within the course of the next calendar year, I needed to see a neurologist for the seizures, also a metabolic physician for the diabetes, a family doctor for depression and anxiety and also a gastroenterologist for my gut.

Whew!

While at the gastroenterologist, I had a colonoscopy and has been diagnosed with IBS.

Melancholy was also taking over my life, so that I found a therapist to sort out all my stress and anxiety (that I understand has played a large role in all my health problems ).

Somehow, during all of this, I kept telling myself”I’ll get better” because I searched for a new diet and lifestyle.

Input The SCD Diet…

I started researching how to assist diabetes and stomach problems and that’s when I found that the SCD Diet. I read the book “Breaking the Vicious Cycle” and chose to leap in.

The next tools helped me heal:

The intro diet required awhile before I got the hang of it, but I stuck with it. I wanted it to be a quick fix in the beginning, and I now know that health is not about quick fixes.

My Life Today

My stomach issues have improved, however, it’s a work in progress.

My diabetes is almost to the point of change – I’m so close to not needing it! Over the last two years, my blood glucose is regularly from the 73 to 77 mg/dl range. A1C (blood test measuring moderate blood sugar ) is 5.3 and I want two more visits along with my A1C below 6.0 to technically be considered out of the diabetic selection.

I have not had to choose almost any diabetic medication for three decades – it’s all controlled with diet. The doctors are amazed at my progress!

The IBS symptoms have surely improved and I know I am on the right road to full recovery. The pain is no longer a part of my daily life and my burden is stable.

I’m still with this journey of healing, but I’m proud of my small successes on the way.

I’m so grateful to SCD Lifestyle for helping me get my life back.

[Input Jordan]

You may be reading this as you really feel like consuming.

Myself, Steve, Mimi – we had these moments where we doubted if getting healthy was very potential.

It is a normal response to possess if things get tough.

And this is where your attitude and a bit of assistance can go a ways.

If you have started your journey and are looking for support, it is possible to combine the SCD Facebook neighborhood here.

In case you haven’t begun yet and need to TODAY, grab a copy of our eBook and let us assist you to take your health back.

We’re here to help!

Jordan

The post How Mimi’s Together With The SCD Diet To Type 2 Diabetes appeared first on Healthy Gut Business .

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Sjögren’s Syndrome: What Causes It And How To Overcome It Naturally

Sjogren's Syndrome

I have what?

Apart from being hard to declare, Sjögren’s syndrome is an autoimmune condition whose unpredictable nature makes it hard to diagnose and handle.

Those who really receive a timely identification are often left feeling fearful and confused, since they attempt to grasp what it actually means to live with a seemingly mysterious disease.

Unfortunately, many believe they have no other option than to go down the rabbit hole of lifelong drugs with unrelenting side effects.

You will wonder if additional choices even exist….

They DO.

In case you’re trying to find a different choice but don’t know where to begin, you are in the perfect place.

Continue reading, as we dip right into that which contributing factors ignite this disease, what function the intestine plays in turning it to, what you could do to conquer Sjögren’s obviously and a lot more.

What’s Sjögren’s Syndrome?

Sjögren’s syndrome (pronounced SHOW-grins) is the 2nd most frequent autoimmune disease in the world. It primarily impacts the salivary (mouth) and lacrimal (eye) glands, which under ordinary circumstances help produce moisture in the form of tears and saliva.

For Those Who Have Sjögren’s, the body fails to produce enough moisture…

That May Lead to a whole host of symptoms like:

  • Dry mouth and eyes
  • Issue swallowing/eating
  • Blurred vision/ Burning feeling in your eyes
  • Hoarseness/non-productive cough
  • Recurrent mouth infections

Even not as frequent, Sjögren’s can actually affect the entire body. Sometimes, it may lead to systemic symptoms such as fatigue, rashes, dry skin and joint soreness. In one analysis, 67 percent of patients reported having an abnormal amount of exhaustion on daily basis.

As many as 4 million individuals live with Sjögren’s – a condition called after the swedish ophthalmologist Henrik Sjögren who explained the symptoms in 1933. Regardless of the range of individuals afflicted by this illness, it’s uncommon for two individuals to present with the exact same symptoms.

And this is why a suitable examination is so important in regards to getting the ideal diagnosis.

Diagnostic Tools to Sjögren’s Outcomes

No single diagnostic evaluation is sufficient to confirm a diagnosis, but rather a succession of approaches are utilized. Performing a physical examination and reviewing the patient’s medical history is a good starting place, followed closely by an Antinuclear Antibody (ANA) blood test.

A particular X-ray of the salivary glands, called a sialogram, can help determine if the salivary gland or duct is blocked. A biopsy of the salivary glands might help ascertain whether inflammation is present, and if so, the severity. Most reachable for a biopsy are the small salivary glands just under the inner surface of the lip – which is a test commonly known as a lip biopsy.

The Schirmer tear test is a test used to determine the degree of moisture from the eye and acts as a fantastic indicator of how far the eyes are being influenced.

Individuals diagnosed are classified as either primary or secondary. Principal Sjögren’s syndrome tends to be aggressive and happens in those people who do not have some other autoimmune conditions. Secondary Sjögren’s happens in people who already have another autoimmune disorder using scleroderma, lupus, and Rheumatoid Arthritis being the most frequent.

Most individuals are well in their 40’s before they are diagnosed and women are 9 times more likely to develop the disease than men.

Complications of Sjögren’s Syndrome

In some cases, it’s possible for people suffering from Sjögren’s to experience complications from different areas like the kidneys and lymph nodes.

It’s estimated that 9–24 percent of patients having Sjögren’s suffer with lung troubles, which can lead to increased risk of mortality.

The most serious complication of Sjögren’s is Non-Hodgkin’s Lymphoma (NHL) – a type of cancer that starts in lymphatic cells (those cells are a part of the immune system). For all those who have Sjögren’s, it happens most commonly in the salivary glands.

The probability of developing NHL is equal for both secondary and primary Sjögren’s and some studies estimate the risk to be 44 times greater than that detected in a wholesome population.

Persistent enhancement of a significant salivary gland should be carefully and regularly observed by your physician and researched further if the dimension changes.

Other symptoms to be aware of are:

  • Unexplained fever and weight loss
  • night sweats
  • unrelenting fatigue
  • reddened patches on skin

The Genetic Link in Sjögren’s Infection

The Genetic Link in Sjogren's Syndrome

As seen in our autoimmune series of articles, nearly every state has a genetic element and Sjögren’s is not any different.

Research has discovered the STAT4 gene version related to rheumatoid arthritis and lupus is also associated with chief Sjögren’s syndrome (pSS). At a recent case control study, the probability of developing Sjogren’s was seven times higher one of first-degree relatives with autoimmune disease compared to management group.

Another study replicated these observations by showing that first-degree loved ones of Sjogren’s patients had an increased risk of creating the illness (as well as systemic lupus, RA, systemic diseases, along with type 1 diabetes) compared to the general population.

Both studies above, as well as several other people, strongly suggest a genetic effect in the growth of Sjögren’s syndrome. Researchers also recognize the genes do not act independently. It is probably the mix of ecological exposures and genetics are what evoke an autoimmune disease.

Contributing Factors in Progress of Sjögren’s Syndrome

Factors which result in the onset of autoimmune disorders are crucial to understanding how to manage the condition naturally.

The most frequent contributing factors in Sjögren’s syndrome are:

Viral Infection – Researchers discovered that a chronic cytomegalovirus (CMV) infection could cause the growth of Sjögren’s. The persistence of CMV may commence tissue degradation in genetically susceptible people by assaulting the salivary and lacrimal glands via antigenic expression. Finally, this can cause the manifestation of Sjogren’s syndrome.

Studies also show a correlation involving an Epstein Barr Virus (EBV) infection and the pathogenesis (development of disorder ) of both Sjögren’s Syndrome.

Hormones – Since Sjögren’s syndrome displays such a large female prejudice, genetic makeup is an intuitive area to examine. This study reveals low degrees of the anti inflammatory sexual hormone DHEA is associated with the symptoms found in main Sjögren’s syndrome along with dry mouth symptoms diminished during DHEA treatment.

Anxiety – Persistent physical, emotional and mental stress all have the ability to lower the body’s immune capacities . Not only does this aggravate chronic symptoms, however, also welcome different infections (like those mentioned above). Those suffering from Sjögren’s say the number one cause of a hay or a relapse is a stressful event. When it’s taking a short walk or integrating a daily meditation routine, discovering ways to destress is a important part of managing the problem.

Sjögren’s Syndrome and the Digestive System

Simply place, Sjögren’s syndrome can wreak havoc on the digestive tract and impair quality of your life. Researchers estimate over 25 percent have moderate to severe gastrointestinal issues.

The most common digestive complaints of those with Sjögren’s are:

Constipation – Sufficient moisture is required to have a perfect, type 4 on the bristol feces chart. Constipation issues might be a consequence of the diminished fluid in the intestinal tract if less saliva is produced. A possible connection between the effect of Sjögren’s and the smooth muscle that propels food along the intestines is now being analyzed, but there aren’t any definitive results at the time.

Chronic Atrophic Gastritis – Also called inflammation of the gut lining, gastritis frequently results from the gradual deterioration of their protective mucosa from the gut. This may lead to a decrease in stomach acid, which is important for optimum digestion. Studies reveal gastritis occurs more commonly in Sjögren’s syndrome patients versus wholesome individuals.

Gastroesophageal Reflux (GERD) Appropriate stomach acid amounts are needed to prevent infections at bay and to correctly break down foods. In contrast to popular belief, it is really the lack of stomach acid that is probably the reason for GERD (vs. too much acid). Testing your acid levels and supplementing with Betaine HCl if mandatory is a great place to begin in getting to the bottom of acid reflux.

Coeliac Disease (CD) – More commonly known as Celiac diseasethis problem is characterized by inflammation of the small intestine and villus atrophy which is in part because of gluten exposure. A study discovered that Celiac disease can be identified in 5 34 Sjögren’s syndrome patients (14.7%).

Irritable Bowel Syndrome (IBS) – IBS is characterized by pain or discomfort in the stomach region along with gut changes and happens in around 15% of the population. In patients with Sjögren’s syndrome, IBS has been proven to influence 39-65% versus 9-15% in healthy controls. Physicians and researchers have identified that a root cause of IBS – in up to 84 percent of IBS instances it is SIBO (small intestine bacterial vaginosis ).

It may be overwhelming to see all of these complaints as separate ailments wholly independent of one another. The fantastic news is they’re actually all linked.

The Leaky Gut – Autoimmune Link

The Leaky Gut - Autoimmune Connection

Leaky gut areas an unrelenting need in the immune system. This is especially harmful for those battling an autoimmune condition with an immune system working overtime.

One expert summarized it this way:

“Leaky gut syndrome is virtually always related to autoimmune disease. In fact, reversing signs of autoimmune disease is dependent on curing the lining of the gastrointestinal tract. Any other treatment is merely symptom suppression.” – Dr. Jill Carnahan, MD

Another specialist, Alessio Fasano, M.D., has been in the forefront of pancreatic disease study and published a paper titled”Leaky Gut and Autoimmune Diseases.”

His findings have shown that for an autoimmune disease to develop, 3 states must all exist :

  1. An hereditary predisposition to autoimmunity (i.e. STAT4 gene at Sjögren’s)
  2. An exposure to this environmental cause (i.e. Viral Infection)
  3. Improved intestinal permeability (a.k.a. Leaky Gut Syndrome)

It may be unsettling to notice this a leaky gut plays a major part in the creation of autoimmunity… but we have good news. It is 1 factor that’s fully in our hands and, beyond that, it could be healed using all the right plan.

Talking of a plan, allow ’s’ consider exactly what mainstream medicine offers.

Medical Treatment for Sjögren’s – Hurtful or Useful?

Prescription drugs remain the cornerstone for the conventional remedy of Sjögren’s syndrome. The target is to take care of the many symptoms that can arise, in dry eyes and mouth to joint pain and fatigue.

The most popular medicine used to deal with systemwide complications is methotrexate (Trexall), an aggressive drug designed to suppress the immune system. Many patients do report symptoms, but are not easy to point out the side effects too.

The most common side effects of methotrexate are nausea, vomiting, stomach pain, drowsiness, temporary hair loss and nausea. And though this drug is shown to decrease the main signs of dry mouth and eyes, this research reveals target parameters did not change.

What exactly does that mean?

It means that although symptoms seemed to enhance, actual evaluation measures showed no distinction.   To put it differently, it can be considered as a band-aid form of treatment.

Studies such as this (along with the negative effects of most drugs) leave us with several questions, when it comes to finding the Perfect treatment plan:

  • What kind of therapy do I need (quick fix vs. continuing treatment)
  • Are the side effects of medications worthwhile?
  • Just how much am I prepared to spend on drugs?
  • Exactly what occurs when the drug no longer works?
  • Do natural remedies exist?

Until now, you may have thought the medical route was the only alternative. But, thankfully, there’s another manner.

How To Turn Off Autoimmune Disease

The ability of this human microbiome just cannot be refused.

Hippocrates, the famous Greek physician, was conscious of the even 2,000 years ago when he said”all disease starts in the gut.” As early and current wisdom suggests, the very best place to start is the gut and we’re here to help you do just that.

Jordan and Steve hosted on a free webinar called,”How To Switch Your Autoimmunity and Restore a Healthy Immune System.”

It’s completely FREE and you can register for your seat here: https://healthygut.com/autoimmune-webinar/

The topic of autoimmunity is complicated and the total amount of info out there may be overpowering. That is why we’ve completed the job for you and are grateful to encourage you on this journey – all you need to do is register here.

– Lori Jo

P.S. – Don’t worry if you can not attend live, we will send you some free replay another day when you register here.

P.P.S – Let’s know what you are struggling with at the remarks below.

The article Sjögren’s Syndrome: What Causes It And How To Conquer It Obviously appeared first on Healthy Gut Company.

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Whole 30: Days 15-17… Halloween Candy – yikes!

Now is Halloween… has Never been too hard… YET.  

We are heading out to proceed trick-or-treating in roughly half an hour and as soon as the candy comes back IN the home, that will be when the challenge begins.

I have branched out with a few more recipes within the last day or two.   Some good, some fine.   I’ve discovered that I am undoubtedly less thirsty than I have been in some time.   This Is Fantastic!   So here are the past few days…

  • Supper 1:
  • Dinner two:  2 bacon and eggs; sweet potato chips
  • Meal 3:  Coconut Curry poultry and cauliflower rice.   DELICIOUS!   I didn’t believe I liked curry, however my daughter insisted I make it and it was very yummy.   Definitely a keeper.

Day 16:

  • Supper 1:  Egg with avocado, banana
  • Meal 2: Pumpkin un-oatmeal with walnuts, scrambled egg  (“oatmeal” was okay, wouldn’t do it again)
  • Dinner 3:  Pork chops and apple sauce, salad
  • Supper 1:  Banana, 1 egg scrambled with vegetables and bacon
  • Dinner 3:  Hamburgers and sweet potato fries and apple sauce
  • Bite:  Almond milk latte, terra processors

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Friday Faves

xoxo

Which movie chef gets the ideal food?
Loft is 60% off with code HBDUSA. A few friends have this jumpsuit and it fits them perfectly, so that I might need to do it.
Old Navy up to 60% off everything. It is hard to believe that back-to-school shopping is right around the corner.

I wished to say thank you for each of the beautiful and heartfelt remarks, DMstexts, and even mails in response to my final post. Whenever I go out on a limb, it disturbs me to know how many of you feel the exact same way. So many of us are juggling a lot of jobs, feeling that the pressure to always accomplish more, and the continuous need to stay busy and moving. I hope you will join me in simply evaluating what’s essential, what is fun, what is well worth it, and take time for yourself each day. I believe a good deal of the pressure I had been feeling was self-imposed; constantly adding more on my plate since I could, and not necessarily *should. * 

(Dress here along with my fave everyday shoes are here)

The post Friday Faves appeared first on The Fitnessista.
Just in case you needed to read this, also.

Get in a brief burst of energy for brain health.

We are here in San Diego for a couple of days, and loving being back in the shore and back in all of our regular spots. The new ocean air feels excellent, and I’m excited about spending some time with our SD friends for a bit.
Hi friends! Happy weekend to ya. I hope you had a excellent 4th!

Fashion + beauty:

You’ve got a short-sleeve variant of my favourite side tie gown.
W p at ob noodleOb noodle

Happy Friday, friends. Thanks for hanging out together here on the website today.
Express up to 50% off everything.
Countertime
Keanu Reeves as each Disney prince.

W bets

Read, observe, listen:

Athleta swimwear is 40% off. This rash protector is super cute.

How strength training impacts metabolism
I recently ordered this shirt and the cloth is a dream.

Swim day

For now, it’s time for the weekly Friday Faves celebration! That is where I share some of my fave finds out of the week and about the web. I love to hear what you are appreciating also, so please shout out a fave in the comments below.
(Maxi is here)
Also, my articles around here might change! I will focus on writing more about the things that excite me and that I believe that you’d love to read about, and not necessarily posts that I think would be immobilized a ton or shared. There will still be plenty of fitness and life content, however I’d love to focus more on some subjects like the following: mom hacks, quick workouts you can do anywhere, fast staple meal thoughts, daily casual uniforms, meditation, mindfulness, etc.. If you have any requests or anything you’d love to see, please allow me to know!

The newest Countertime series launches on Tuesday! I’ll have a complete article up with all the details, however I.can’t.wait for you to have it! I have been using the new line for about a month and I am totally obsessed. The nighttime cream feels just like La Mer and also the new plant-based retinol is a dream.
Gina

(This really is from the sample that they sent after LEAD and I’ve barely made a dent in it, even despite using it every evening. A bit goes a long way! It is super luxe and moisturizing.)
Ocean beach

ALL Fit Guides are 30 off this weekend with code FREEDOM. Take the quiz here and determine that which Fit Guide will be the best match for you! (If you have any questions, please let me know.)

Great eats:

I’ll be here blogging and doing my own thing, but I am taking the next few weeks to learn what jobs I can outsource or eliminate. Taking care of these girls is my #1 task, but for so long, I have been rolling along within this area without respecting the simple fact that it’s also a full-time job. Beyond writing articles, there is a lot of behind-the-scenes work that goes to this small blog, including never-ending emails, social calendars, sponsored content, brand ventures, recording and editing the podcast, producing videos, creating graphics, Beautycounter, etc. 

This dish peach baked oatmeal is one of my summer faves.

Fit guides

Can not wait to try out these zucchini muffins.
J. Crew up to 50% off using code BIGGEST.

How stunning is this bag?

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Uncharted: The Lost Legacy Gameplay Debuting on June 20

We will also be showing our newest DLC upgrade for Indices 4: Multiplayer and Survival, which will be launching later that day and contained with Uncharted: The Lost Legacy at August.
It has been an amazing week for Naughty Dog in E3. We opened the PlayStation Press Seminar with our all-new trailer for Uncharted: The Lost Legacy and over the past couple of days, we have had a packed schedule of live shows, interviews, along with demoing never before seen gameplay at the PlayStation booth. Thank you!

Howeverwe wanted to ensure everyone following along from home would also have a opportunity to observe the E3 demonstration. Following Tuesday, June 20, we’re definitely going to be debuting our E3 gameplay demo by Uncharted: The Lost Legacy gameplay live Twitch.tv/NaughtyDog, beginning at 10:00am PT/1:00pm  ET/7:00pm CET (Discover Your Time Zone).   Tune into listen to by Creative Director, Shaun Escayg, and Game Director, Kurt Margenau since they share more information about the sport and answer viewers questions.

For more upgrades, keep an eye on our official TwitterFacebook, and Instagram stations.

You won’t need to miss this.

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